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Beekman B, et al

No adverse effects were observed on reproductive parameters when male dogs received 10 consecutive daily treatments of 15 mg/kg/day at 3 intervals (90, 45 and 14 days) prior to breeding or when female dogs received 10 consecutive daily treatments of 15 mg/kg/day at 4 intervals: between 30 and 0 days prior to breeding, early pregnancy (between 10th & 30th days), late pregnancy (between 40th & 60th days), and during lactation (the first 28 days)

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Figure 7 presents the average vertical RMSEs for the two DA experiments using the 1/12 model, which shows a similar degradation of BOTH for the subsurface temperature and salinity as shown previously in the 1/4 eddy permitting model